TRILUMINEX
A DIVISION OF INTERCHEM TECHNOLOGIES
Nutraceuticals, Nutritional Supplements and Alternative Medicine
Background
Triluminex is a division of Interchem Technologies which has recently developed exciting new products known as BRM or Biological Response Modifiers for the nutraceutical and alternative medicine arena with emphasis on Anti-Aging, Cancer, and Heart Disease [1],as part of its CDX Complexes. In addition Triluminex has developed a super molecular nanotechnology to make these, otherwise, insoluble compounds soluble and therefore bio-available for the human body via complexing with cyclodextrins.
Most of the products in the nutraceutical health food arena we tested have shown little or no solubility and lack bioavailability as they pass through the digestive system unchanged. Whereas our products, as Cyclodextrin complexes or CDX-complexes stay in solution as nano particles, which makes them highly absorbable or bio-available. The unique process is called “Super molecular Technology” which makes use of natural “host cavities” of the various cyclodextrins hic can be filled with smaller diameter “guest molecules” thus creating a new “Super molecule”[2]
Triluminex super molecular technology is demonstrated in the following picture: The content of capsules of competitive products and our product diluted in water.
The other products do not dissolve or gum-up whereas our product stays suspended in solution. Which product would you rather take?
The following products have been developed by Triluminex with focus on the Anti-Aging, Cardio-Vascular and Cancer arenas:
NEOLITE™ -THE ULTIMATE SWEETENER
With obesity, heart disease, diabetes, and cancer reaching epidemic proportions, it is more important than ever to find a healthy, safe, low-calorie substitute for Sugar, High Fructose Corn syrup contributors to massive health problems and Artificial Super Sweeteners (Aspartame, Sucralose, Saccharin etc.) that are known to be controversial worldwide and also cause inflammatory bowel disease (IBD).
A true breakthrough in low-calorie sweeteners - TOTAL SUGAR REPLACEMENT
FLAVOR ENHANCER
LOW GLYCEMIC
LOW CALORIE
PROBIOTIC
MAY HELP IMPROVE INTESTINAL HEALTH
HEART HEALTHY
NON-CARCINOGENIC
NON-GMO
VEGAN
KOSHER
Uses for Neolite™
4 Low-calorie sugar replacement CAN BE LABELED 0 CALORIES
4 Soft drinks
4 Baked goods
4 Dairy products
4 Ice Cream
4 Gelatin products / puddings
4 Jams and Jellies
4 Cereals
4 Medicines
4 Oral care products
4 Chewing gum
4 Diabetic-friendly products
Advantages of Neolite™
4 Less than one calorie per gram.
4 Low glycemic index.
4 Diabetic-friendly.
4 Good for low-carb diets.
4 Natural flavor enhancer.
4 Heat-stable for baking.
4 Stable at pH extremes.
4 Competitively priced.
4 Naturally-derived ingredients
4 meet FDA’s GRAS standards.
4 All ingredients meet EU
4 Excellent taste, flavor enhance
Serving Size: 1 tsp. (5 g)
Calories: 0
% Daily Value*
Fat 0%
Transfat 0%
Cholesterol 0%
Carbs. Less than 2 g 0%
Protein 0%
Not a significant source of sugars, vitamin A, vitamin C, calcium, and iron.
*percent daily value, based on a 2000 calorie per day diet.
INGREDIENTS: Probiotioc Fiber, Organic Agave Syrup , Citrosa® an natural derivative extracted from seville Oranges.
UNDER DEVELOPMENT
ICARITIN
Icaritin is a phytopharmaceutical, flavanoid, glycoside naturally derived from Epimedium an herb found in Southern China and the Mediterranean.
Epimedium Sagittatum, widely known as “horny goat weed”, was originally used medicinal Chinese Medicine. It is widely used as a tonic for erectile dysfunction and as an anti-rheumatic in China, Japan and Korea.
Icaritin has huge potential to be developed as a naturally derived, selective phytopharmaceutical or orphan drug (cytostatic chemo- therapeutic).
And as a side bonus, Icaritin was also found to be a potent erectile dysfunction inhibitor with a potential of becoming a natural “Viagra”.
For the most part, the standard drug therapy for cancer in classic medicine uses cytostatic chemotherapeutics which, at ideal conditions, arrest or destroy tumor cells. But they cause severe side effects, and consequently reduce the quality of life. In most cases these drugs cannot heal cancer patients or extend their lifespan more than 5-10 years. Clinical trials have shown that
Icaritin is not toxic to the human body, it is selective in destroying cancer cells only, and it practically has no known side effects.
Icaritin and Desmethylicaritin are difficult to manufacture using the present process and are only available at very high prices as research compounds as there is no commercial process available.
So far, Triluminex has spent considerable time and money to develop a commercial process for this highly effective compound.
In Phase 1: The objective was to convert herbal epimedium 60%
Into 90% or greater Icariin. This phase of the project was partially funded and completed. The system was validated using analytical equipment NMR and HPLC.
Phase 2: Development of Cyclodextrin complex of Icariin, is completed.
Phase 3: The enzymatic production of Icaritin needs to be funded. With this newly discovered, exciting, and dynamic compound It is our mandate to produce pure Icaritin based on research.
BETACARBOTRIN-CDX-COMPLEX
Cancer Specific.
Beta Carbotrin-CDX-complex ( chemical name = Nicotinic Acid Disulfide) has been widely found to have anti metastatic and anti-mutagenic properties and high activity as a nontoxic, slightly euphoric, PARP inhibitor. This product is an ideal adjuvant for any cancer therapy and chemotherapy and should be taken by any one on or off cancer treatment as a preventative.
GLUTALUXE-ACETYLGLUTATHION-CDX-COMPLEX
The Master Anti-Oxidant. The new anti-aging pill.
Glutathione, a tri-peptide, is an essential anti-oxidant, anti-toxin, and a protector of DNA and cell health.
Research has also shown that Acetyl Glutathione, taken orally or in a cosmetic cream can also whiten the skin and even out blemishes and scars.
As we age our levels of Glutathione is diminished and must be replaced.
As the absorption of pure Glutathione, given as a supplement, is very poor. We have developed a protected molecule pharmaceutically known as Acetyl Glutathione as a CDX complex which makes it highly absorbable and bio-available.
CURCUMIN –CDX-COMPLEX
Natural healing derived from the Turmeric Root.
A multitude of clinical studies have indicated that Curcumin is a therapeutic agent for disease and clinical conditions including cancer, and leukemia, stroke, myocardial infarction, rheumatoid arthritis, inflammatory bowel disease, pancreatitis, sepsis, hemorrhagic shock, organ transplantations, and radiation injury, (loc. cit. references).
Triluminex has developed natural Curcuminoids, available, for the first time, as a unique water nano-particle Cyclodextrin complex which is unprecedented in the history of Curcuminoids or the whole history of Turmeric. The newly bio-available water soluble CDX complex of Curcumin provides absolute concentrations of nano-particles, Curcumin available to the cells, also known as a Biological Response Modifier (BRM).
MAGNOLOL-CDX-COMPLEX
Ancient Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the bark of
the Magnolia trees. In preclinical experiments, Magnolol was found to have anti-oxidative, anti-inflammatory,anti-tumorgenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signaling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects.
Anti-cancer properties + Cardiovascular Properties
Konoshima et al. were the first to demonstrate the effect of magnolol against skin cancer in mice [31]. Magnolol can successfully induce apoptosis in tumor cells, including, cultured
human hepatoma and colon [32] cancer cells, lung squamous [33] and thyroid [34] carcinoma, melanoma [35,36], fibrosarcoma,monocytic leukemia [35,37,38] and prostate [39] cancer
cells [40]. Li et al. reported that magnolol in human nonsmall lung cancer cells, induced cell death, not by an apoptotic pathway but rather by autophagy [41]. Magnolol successfully
inhibits experimentally induced liver and spleen metastasis using lymphoma and melanoma models [42] (Fig. 4).
Triluminex has successfully developed the CDX-complex of Magnolol making the compound
Bio available to the human body.
TERRASIL®-(PTEROSTILBENE)–CDX complex
Pterostilbene, America’s hottest Anti-Oxidant, occurs naturally in grapes and berries, especially blueberries. It is closely related to resveratrol and shows many of the same characteristics, as well as its own unique therapeutic potential. Ayurvedic medicine cites well-known Indian herbal preparation of Vitis vinifera that contains pterostilbene and is prescribed as a cardiotonic. It is also suggested that pterostilbene might be one of the principal antidiabetic constituents. Pterostilbene is known to have pharmacological benefits for prevention and treatment of a wide variety of diseases, including diabetes, cancer, cardiovascular degeneration and pain. As a potent chemopreventative, antioxidant, and anti-inflammatory agent, pterostilbene has the potential to ameliorate the effects of aging when used by healthy individuals.
ASTAXANTHIN-CDX-COMPLEX
Derived from marine algae cultivated in the warm waters of Hawaii's Kona Coast, Asaxanthin is a carotenoid that acts as an antioxidant to protect our cells from free radicals.
Astaxanthin prevents the initiation of cancer cells in the tongue, oral cavity, large bowel, bladder, uterus, and breast.
Astaxanthin shields cells and mitochondrial membranes from oxidative damage,
Astaxanthin inhibits lipid peroxidation that causes plaque formation, thus, reducing risk of cardiovascular disease.
Astaxanthin alleviates stress and may assist in neurodegenerative conditions such as AMD, Alzheimer's, Parkinson's, ALS.
Astaxanthin protects the eyes and skin from UVA and UVB Astaxanthin reduces the number of new and abnormal cells in the liver.
MEGA COENZYME Q-10-CDX-COMPLEX
CoQ10
MegaCoQ10®
•High Solubility
•Bioactive
Most people over 40 need to consume CoQ10 as a daily supplement, especially those with heart conditions as well as cancers. The same applies to those who take statin (cholesterol-lowering) drugs for treatment of high cholesterol.
Coenzyme Q10 appears to help ignite cellular power stations that are necessary to maintain healthy cells, enhancing energy at the cellular level. This powerful antioxidant is highly concentrated in heart muscle cells and was first widely taken in Japan to stimulate heart muscle cells of geriatrics. Around the world it is widely applied to food supplements (even toothpaste) and cosmetics in USA and as well as many other countries; it is GRAS certified (generally recognized as safe by FDA).
However, its bioavailability is low and variable due to its poor solubility and high molecular weight.
Triluminex MegaCoQ10® is unique compared to any other form of CoQ10.
Almost all brands of CoQ10 will not dissolve in body fluids or water. CoQ10’s bioavailability is like oil mixed in water.
Mega CoQ10 CDX complex protects molecules through the stomach acids & enzymes into the intestines for enhanced bioavailability ~10 fold.
Doxorubicin, for example, a chemotherapeutic agent, is known to sometimes damage the heart permanently. But use with coenzyme Q10 may reduce this toxic effect.
Coenzyme Q10 was first identified in 1957. Its chemical structure was determined in 1958. Interest in coenzyme Q10 as a potential treatment for cancer began in 1961, when a deficiency of the enzyme was noted in the blood of cancer patients. Low blood levels of coenzyme Q10 have been found in some patients with myeloma (a malignant tumor that develops in the blood-cell-producing cells of the bone marrow), lymphoma (cancer of the lymph nodes), and cancers of the breast, lung, prostate, pancreas, colon, kidney, and head and neck, according to the National Cancer Institute (NCI).
More products will be listed as they are developed for the consumer market. The above technologies are available for licensing to appropriate customers.
[1] Research documents and references and clinical literature are available upon request. They were tested and documented in peer review journals. The compounds are labeled Immune Boosters or Nutritional Supplements according to DSHEA.
[2] A more detailed explanation of how this works is available on request, suffice it to say it converts an insoluble substance to a bioavailable substance which has a tremendous market in the nutraceutical and pharmaceutical industries.
A DIVISION OF INTERCHEM TECHNOLOGIES
Nutraceuticals, Nutritional Supplements and Alternative Medicine
Background
Triluminex is a division of Interchem Technologies which has recently developed exciting new products known as BRM or Biological Response Modifiers for the nutraceutical and alternative medicine arena with emphasis on Anti-Aging, Cancer, and Heart Disease [1],as part of its CDX Complexes. In addition Triluminex has developed a super molecular nanotechnology to make these, otherwise, insoluble compounds soluble and therefore bio-available for the human body via complexing with cyclodextrins.
Most of the products in the nutraceutical health food arena we tested have shown little or no solubility and lack bioavailability as they pass through the digestive system unchanged. Whereas our products, as Cyclodextrin complexes or CDX-complexes stay in solution as nano particles, which makes them highly absorbable or bio-available. The unique process is called “Super molecular Technology” which makes use of natural “host cavities” of the various cyclodextrins hic can be filled with smaller diameter “guest molecules” thus creating a new “Super molecule”[2]
Triluminex super molecular technology is demonstrated in the following picture: The content of capsules of competitive products and our product diluted in water.
The other products do not dissolve or gum-up whereas our product stays suspended in solution. Which product would you rather take?
The following products have been developed by Triluminex with focus on the Anti-Aging, Cardio-Vascular and Cancer arenas:
NEOLITE™ -THE ULTIMATE SWEETENER
With obesity, heart disease, diabetes, and cancer reaching epidemic proportions, it is more important than ever to find a healthy, safe, low-calorie substitute for Sugar, High Fructose Corn syrup contributors to massive health problems and Artificial Super Sweeteners (Aspartame, Sucralose, Saccharin etc.) that are known to be controversial worldwide and also cause inflammatory bowel disease (IBD).
A true breakthrough in low-calorie sweeteners - TOTAL SUGAR REPLACEMENT
FLAVOR ENHANCER
LOW GLYCEMIC
LOW CALORIE
PROBIOTIC
MAY HELP IMPROVE INTESTINAL HEALTH
HEART HEALTHY
NON-CARCINOGENIC
NON-GMO
VEGAN
KOSHER
Uses for Neolite™
4 Low-calorie sugar replacement CAN BE LABELED 0 CALORIES
4 Soft drinks
4 Baked goods
4 Dairy products
4 Ice Cream
4 Gelatin products / puddings
4 Jams and Jellies
4 Cereals
4 Medicines
4 Oral care products
4 Chewing gum
4 Diabetic-friendly products
Advantages of Neolite™
4 Less than one calorie per gram.
4 Low glycemic index.
4 Diabetic-friendly.
4 Good for low-carb diets.
4 Natural flavor enhancer.
4 Heat-stable for baking.
4 Stable at pH extremes.
4 Competitively priced.
4 Naturally-derived ingredients
4 meet FDA’s GRAS standards.
4 All ingredients meet EU
4 Excellent taste, flavor enhance
Serving Size: 1 tsp. (5 g)
Calories: 0
% Daily Value*
Fat 0%
Transfat 0%
Cholesterol 0%
Carbs. Less than 2 g 0%
Protein 0%
Not a significant source of sugars, vitamin A, vitamin C, calcium, and iron.
*percent daily value, based on a 2000 calorie per day diet.
INGREDIENTS: Probiotioc Fiber, Organic Agave Syrup , Citrosa® an natural derivative extracted from seville Oranges.
UNDER DEVELOPMENT
ICARITIN
Icaritin is a phytopharmaceutical, flavanoid, glycoside naturally derived from Epimedium an herb found in Southern China and the Mediterranean.
Epimedium Sagittatum, widely known as “horny goat weed”, was originally used medicinal Chinese Medicine. It is widely used as a tonic for erectile dysfunction and as an anti-rheumatic in China, Japan and Korea.
Icaritin has huge potential to be developed as a naturally derived, selective phytopharmaceutical or orphan drug (cytostatic chemo- therapeutic).
And as a side bonus, Icaritin was also found to be a potent erectile dysfunction inhibitor with a potential of becoming a natural “Viagra”.
For the most part, the standard drug therapy for cancer in classic medicine uses cytostatic chemotherapeutics which, at ideal conditions, arrest or destroy tumor cells. But they cause severe side effects, and consequently reduce the quality of life. In most cases these drugs cannot heal cancer patients or extend their lifespan more than 5-10 years. Clinical trials have shown that
Icaritin is not toxic to the human body, it is selective in destroying cancer cells only, and it practically has no known side effects.
Icaritin and Desmethylicaritin are difficult to manufacture using the present process and are only available at very high prices as research compounds as there is no commercial process available.
So far, Triluminex has spent considerable time and money to develop a commercial process for this highly effective compound.
In Phase 1: The objective was to convert herbal epimedium 60%
Into 90% or greater Icariin. This phase of the project was partially funded and completed. The system was validated using analytical equipment NMR and HPLC.
Phase 2: Development of Cyclodextrin complex of Icariin, is completed.
Phase 3: The enzymatic production of Icaritin needs to be funded. With this newly discovered, exciting, and dynamic compound It is our mandate to produce pure Icaritin based on research.
BETACARBOTRIN-CDX-COMPLEX
Cancer Specific.
Beta Carbotrin-CDX-complex ( chemical name = Nicotinic Acid Disulfide) has been widely found to have anti metastatic and anti-mutagenic properties and high activity as a nontoxic, slightly euphoric, PARP inhibitor. This product is an ideal adjuvant for any cancer therapy and chemotherapy and should be taken by any one on or off cancer treatment as a preventative.
GLUTALUXE-ACETYLGLUTATHION-CDX-COMPLEX
The Master Anti-Oxidant. The new anti-aging pill.
Glutathione, a tri-peptide, is an essential anti-oxidant, anti-toxin, and a protector of DNA and cell health.
Research has also shown that Acetyl Glutathione, taken orally or in a cosmetic cream can also whiten the skin and even out blemishes and scars.
As we age our levels of Glutathione is diminished and must be replaced.
As the absorption of pure Glutathione, given as a supplement, is very poor. We have developed a protected molecule pharmaceutically known as Acetyl Glutathione as a CDX complex which makes it highly absorbable and bio-available.
CURCUMIN –CDX-COMPLEX
Natural healing derived from the Turmeric Root.
A multitude of clinical studies have indicated that Curcumin is a therapeutic agent for disease and clinical conditions including cancer, and leukemia, stroke, myocardial infarction, rheumatoid arthritis, inflammatory bowel disease, pancreatitis, sepsis, hemorrhagic shock, organ transplantations, and radiation injury, (loc. cit. references).
Triluminex has developed natural Curcuminoids, available, for the first time, as a unique water nano-particle Cyclodextrin complex which is unprecedented in the history of Curcuminoids or the whole history of Turmeric. The newly bio-available water soluble CDX complex of Curcumin provides absolute concentrations of nano-particles, Curcumin available to the cells, also known as a Biological Response Modifier (BRM).
MAGNOLOL-CDX-COMPLEX
Ancient Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the bark of
the Magnolia trees. In preclinical experiments, Magnolol was found to have anti-oxidative, anti-inflammatory,anti-tumorgenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signaling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects.
Anti-cancer properties + Cardiovascular Properties
Konoshima et al. were the first to demonstrate the effect of magnolol against skin cancer in mice [31]. Magnolol can successfully induce apoptosis in tumor cells, including, cultured
human hepatoma and colon [32] cancer cells, lung squamous [33] and thyroid [34] carcinoma, melanoma [35,36], fibrosarcoma,monocytic leukemia [35,37,38] and prostate [39] cancer
cells [40]. Li et al. reported that magnolol in human nonsmall lung cancer cells, induced cell death, not by an apoptotic pathway but rather by autophagy [41]. Magnolol successfully
inhibits experimentally induced liver and spleen metastasis using lymphoma and melanoma models [42] (Fig. 4).
Triluminex has successfully developed the CDX-complex of Magnolol making the compound
Bio available to the human body.
TERRASIL®-(PTEROSTILBENE)–CDX complex
Pterostilbene, America’s hottest Anti-Oxidant, occurs naturally in grapes and berries, especially blueberries. It is closely related to resveratrol and shows many of the same characteristics, as well as its own unique therapeutic potential. Ayurvedic medicine cites well-known Indian herbal preparation of Vitis vinifera that contains pterostilbene and is prescribed as a cardiotonic. It is also suggested that pterostilbene might be one of the principal antidiabetic constituents. Pterostilbene is known to have pharmacological benefits for prevention and treatment of a wide variety of diseases, including diabetes, cancer, cardiovascular degeneration and pain. As a potent chemopreventative, antioxidant, and anti-inflammatory agent, pterostilbene has the potential to ameliorate the effects of aging when used by healthy individuals.
ASTAXANTHIN-CDX-COMPLEX
Derived from marine algae cultivated in the warm waters of Hawaii's Kona Coast, Asaxanthin is a carotenoid that acts as an antioxidant to protect our cells from free radicals.
Astaxanthin prevents the initiation of cancer cells in the tongue, oral cavity, large bowel, bladder, uterus, and breast.
Astaxanthin shields cells and mitochondrial membranes from oxidative damage,
Astaxanthin inhibits lipid peroxidation that causes plaque formation, thus, reducing risk of cardiovascular disease.
Astaxanthin alleviates stress and may assist in neurodegenerative conditions such as AMD, Alzheimer's, Parkinson's, ALS.
Astaxanthin protects the eyes and skin from UVA and UVB Astaxanthin reduces the number of new and abnormal cells in the liver.
MEGA COENZYME Q-10-CDX-COMPLEX
CoQ10
MegaCoQ10®
•High Solubility
•Bioactive
Most people over 40 need to consume CoQ10 as a daily supplement, especially those with heart conditions as well as cancers. The same applies to those who take statin (cholesterol-lowering) drugs for treatment of high cholesterol.
Coenzyme Q10 appears to help ignite cellular power stations that are necessary to maintain healthy cells, enhancing energy at the cellular level. This powerful antioxidant is highly concentrated in heart muscle cells and was first widely taken in Japan to stimulate heart muscle cells of geriatrics. Around the world it is widely applied to food supplements (even toothpaste) and cosmetics in USA and as well as many other countries; it is GRAS certified (generally recognized as safe by FDA).
However, its bioavailability is low and variable due to its poor solubility and high molecular weight.
Triluminex MegaCoQ10® is unique compared to any other form of CoQ10.
Almost all brands of CoQ10 will not dissolve in body fluids or water. CoQ10’s bioavailability is like oil mixed in water.
Mega CoQ10 CDX complex protects molecules through the stomach acids & enzymes into the intestines for enhanced bioavailability ~10 fold.
Doxorubicin, for example, a chemotherapeutic agent, is known to sometimes damage the heart permanently. But use with coenzyme Q10 may reduce this toxic effect.
Coenzyme Q10 was first identified in 1957. Its chemical structure was determined in 1958. Interest in coenzyme Q10 as a potential treatment for cancer began in 1961, when a deficiency of the enzyme was noted in the blood of cancer patients. Low blood levels of coenzyme Q10 have been found in some patients with myeloma (a malignant tumor that develops in the blood-cell-producing cells of the bone marrow), lymphoma (cancer of the lymph nodes), and cancers of the breast, lung, prostate, pancreas, colon, kidney, and head and neck, according to the National Cancer Institute (NCI).
More products will be listed as they are developed for the consumer market. The above technologies are available for licensing to appropriate customers.
[1] Research documents and references and clinical literature are available upon request. They were tested and documented in peer review journals. The compounds are labeled Immune Boosters or Nutritional Supplements according to DSHEA.
[2] A more detailed explanation of how this works is available on request, suffice it to say it converts an insoluble substance to a bioavailable substance which has a tremendous market in the nutraceutical and pharmaceutical industries.
